Collector car auctions don’t get bigger than Mecum’s annual flagship sale at Osceola Heritage Park in  Kissimmee, Fla. This year’s edition will feature about 4,000 vehicles to be auctioned from January 4 through 15. One main attraction rolling—or roaring—across the block on Saturday, January 14, is a rare, 2003 Ferrari Enzo.

Often regarded as the last in a quartet of analog supercars from the Prancing Horse, its predecessors include the 288 GTO, F40 and F50. The Enzo’s successor was the LaFerrari, whose motive power combined an engine and an electric motor, ushering in a new age of supercars and making models like the Enzo that much more collectible.

Of course, the Enzo was a hot commodity from the get-go, long before hybrid power trains became the standard for the future of high-performance automobiles. Only 399 examples of the Enzo were produced (plus one for the Vatican) between 2002 and 2004, with about 70 destined for the US market. The entire model run was presold to valued Ferrari customers, most of whom were already F40 and F50 owners.

Paralleling Ferrari’s ascendency in Formula 1, development of its ultimate road-going sports car began in 1998 at the behest of the marque’s chairman at the time, Luca Cordero di Montezemolo. The car was radical in appearance,…